Testosterone is a hormone that, while typically associated with men, is crucial to the overall health and well-being of both genders. It’s responsible for more than just masculine characteristics and sex drive; it plays a significant role in various bodily functions, including mood regulation.

However, what happens when testosterone levels fall below normal? Can it lead to mental health issues such as anxiety and depression? 

It’s not uncommon for symptoms of depression and anxiety to surface when testosterone levels are low. This is because low testosterone levels can mimic these conditions and, if left untreated, cause them over time. 

Mental health challenges can therefore, become part of a complex web of physical and mental health issues resulting from low testosterone levels, often referred to as ‘Low T’. While women produce testosterone at lower levels than men, they are not immune to the effects of Low T. 

The Relationship Between Testosterone and Anxiety

Testosterone, an androgen hormone, has a complex relationship with anxiety. It’s not just involved in muscle growth, sexual function, and bone density but also plays a key role in mental health. 

Testosterone influences the neurotransmitters in the brain that are responsible for mood regulation, such as serotonin and dopamine. Thus, when testosterone levels are low, the balance of these neurotransmitters can be disrupted, potentially leading to increased anxiety.

Several studies have explored the link between testosterone and anxiety. They suggest that low testosterone levels can contribute to heightened anxiety levels due to its impact on the brain’s chemical balance. Moreover, chronic anxiety can further reduce testosterone production, creating a vicious cycle that can be difficult to break.

Common Symptoms of Low Testosterone

Low testosterone, often referred to as ‘Low T’, can present a variety of symptoms. These symptoms can range from physical changes to psychological alterations, given that testosterone is a hormone that plays an integral role in many aspects of our health and well-being.

Reduced sex drive

One of the primary roles of testosterone is in driving libido, or sexual desire. Therefore, when testosterone levels drop, it’s not uncommon to experience a corresponding decrease in interest in sexual activity.


Another common symptom of Low T is a persistent feeling of tiredness. This fatigue can persist even when individuals are getting enough sleep, making everyday activities feel increasingly challenging.

Mood changes

Testosterone also plays a role in mood regulation. As such, when levels are low, individuals may find themselves experiencing mood swings, heightened irritability, or even symptoms of depression.

Difficulty in concentration

Some people with Low T might notice a decrease in their cognitive abilities. This can manifest as difficulty focusing on tasks or remembering things.

Weight gain

Low levels of testosterone can lead to an increase in body fat. This can occur even if dietary habits remain unchanged.

Decreased muscle mass

Testosterone is crucial for muscle growth and maintenance. Therefore, when levels are low, individuals may notice a decrease in muscle mass and strength.

It’s important to remember that these symptoms can be indicative of other health conditions as well. If you’re experiencing any of them consistently, it’s advisable to consult with a healthcare professional for a proper diagnosis and treatment plan.

Read More: Why Is My Sex Drive Low?

Common Symptoms of Anxiety

Anxiety is a natural human response to stress. However, when feelings of anxiety become chronic and start interfering with daily life, it could be a sign of an anxiety disorder. Here are some common symptoms associated with this condition:

Excessive worrying

This is often the hallmark of an anxiety disorder. The worry is typically disproportionate to the situation and can be extremely difficult to control.


Individuals suffering from anxiety may frequently feel restless or on edge. This restlessness can make it hard for them to relax or stay still.

Difficulty concentrating

Just like with Low T, anxiety can also impair one’s ability to focus on tasks or remember things.


People with anxiety often find themselves feeling easily annoyed or agitated, which can strain their personal and professional relationships.

Sleep problems

Anxiety can significantly disrupt sleep patterns. This could include trouble falling asleep, staying asleep, or having restless, unsatisfying sleep.

Physical symptoms

Aside from the psychological symptoms, anxiety can also manifest physically. These symptoms may include fatigue, headaches, muscle tension, frequent urination, and stomach aches.

Again, if these symptoms persist and begin to affect your quality of life, it’s crucial to seek help from a healthcare professional. There are numerous treatment options for anxiety, ranging from therapy and medication to lifestyle changes. A combination of these methods is often the most effective approach.

How Hormones Impact Our Mood

Hormones are an essential part of our body’s communication system. These chemical messengers zip around our bloodstream, influencing everything from growth and energy production to how we respond to stress. But one of their most important roles involves affecting our mood.

Certain hormones have been dubbed ‘feel-good’ hormones because they are linked with positive emotions and feelings. These include dopamine, serotonin, endorphins, and oxytocin. Dopamine is often associated with pleasure and reward, while serotonin helps regulate mood, sleep, and appetite. 

A lack of serotonin can lead to depression. Endorphins are released in response to stress or discomfort and can help produce feelings of happiness. Oxytocin, also known as the ‘love hormone,’ is released during positive social interactions like hugging.

In women, hormones such as estrogen and progesterone also significantly impact mood. Changes in these hormones can lead to mood swings, anxiety, and depression, especially during certain times in a woman’s life, like menstruation, childbirth, and menopause.

Do Men with Low Testosterone More Likely to Suffer from Anxiety and Depression?

Testosterone is usually associated with physical strength and libido in men, but it also plays a vital role in mental health. When testosterone levels are low, it can disrupt the balance of hormones and chemicals in the brain, leading to mood swings, anxiety, and depression. 

Men with low testosterone often report feelings of fatigue, irritability, and sadness, which could contribute to a diagnosis of depression or anxiety. Sleep patterns can also be affected, leading to insomnia, which can further increase feelings of anxiety and depression. 

While low testosterone isn’t the only cause of these mental health issues, it’s clear that it plays a significant role.

Related: What Lowers Testosterone Levels?

How To Treat Low Testosterone and Depression

Addressing low testosterone and depression often involves a two-pronged approach. If low testosterone levels are contributing to depression, testosterone replacement therapy (TRT) might be recommended. This therapy involves increasing testosterone levels through injections, patches, or gels.

In addition to TRT, lifestyle changes can also help. Regular exercise, a balanced diet, adequate sleep, and stress management can all contribute to raising natural testosterone levels and improving mood.

For managing depression, cognitive-behavioral therapy (CBT) can be very effective. This type of therapy helps individuals recognize and change negative thought patterns that lead to feelings of depression. Depending on the severity of the depression, antidepressant medications may also be prescribed.

Remember, everyone’s body is different, and what works for one person might not work for another. It’s important to consult with a healthcare professional to create a personalized treatment plan. And always remember, if you’re struggling with feelings of depression or anxiety, reach out to a healthcare provider. There’s no need to face these challenges alone, and help is available.


Can low testosterone cause anxiety or panic attacks?

Yes, low testosterone can contribute to feelings of anxiety. Testosterone plays a role in regulating mood, and when levels are low, it can disrupt the balance of hormones and chemicals in the brain, leading to mood swings and heightened anxiety. While it’s not the sole cause of anxiety or panic attacks, low testosterone can certainly exacerbate these conditions.

Will testosterone help with anxiety?

Testosterone replacement therapy (TRT) can help reduce symptoms of anxiety in some men with low testosterone levels. By restoring hormone levels to a healthy range, TRT can help balance mood and alleviate anxiety. 

However, it’s important to remember that TRT is just one piece of the puzzle. A comprehensive approach that includes therapy, lifestyle changes, and possibly medication is often the most effective way to manage anxiety.

What are the mental symptoms of low testosterone?

Low testosterone can lead to a variety of mental and emotional symptoms. Men with low testosterone often report feelings of fatigue, irritability, and depression. 

Difficulty concentrating, memory problems, and reduced motivation or self-confidence are also common. If you’re experiencing these symptoms, it’s important to speak with a healthcare provider. They can help determine if low testosterone is the cause and guide you on the best course of treatment.

Reclaiming Emotional Balance with TRT

As we delve into the psychological impacts of hormonal imbalances, it becomes clear that low testosterone levels are not just about physical changes; they also encroach on our mental health, potentially triggering anxiety and depression. Best TRT understands these multifaceted implications and, as a leading online TRT provider, stands ready to assist those grappling with the emotional weight brought on by hormonal declines. Our approach goes beyond superficial treatment, focusing on harmonizing the body’s intricate systems, thereby restoring not just hormonal levels but also a sense of mental well-being.

Reach out to Best TRT, and let’s chart a course together towards emotional stability and renewed vitality. Start your tailored TRT program today, designed with your holistic health in mind, and embrace the transformation that awaits. Your journey to reclaiming joy and peace of mind begins with this empowering decision.

Schedule Your Free TRT Consultation Here

author avatar

James Harrington

James Harrington stands as a leading authority in testosterone replacement therapy (TRT). With rigorous academic training and deep-rooted experience in health and wellness, he offers unparalleled expertise to Best TRT. His blend of scholarly knowledge and real-world experience makes him an indispensable guide for anyone delving into the intricacies of TRT.

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